Sodium gualenate

CAS No. 6223-35-4

Sodium gualenate( Guaiazulenesulfonate sodium )

Catalog No. M20600 CAS No. 6223-35-4

Sodium gualenate (Guaiazulenesulfonate sodium) a hydrophilic derivative of guaiazulene (GA) is an unstable compound.?It has anti-inflammatory and wound-healing effects.??

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sodium gualenate
  • Note
    Research use only, not for human use.
  • Brief Description
    Sodium gualenate (Guaiazulenesulfonate sodium) a hydrophilic derivative of guaiazulene (GA) is an unstable compound.?It has anti-inflammatory and wound-healing effects.??
  • Description
    Sodium gualenate (Guaiazulenesulfonate sodium) a hydrophilic derivative of guaiazulene (GA) is an unstable compound.?It has anti-inflammatory and wound-healing effects.??(In Vitro):Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP.(In Vivo):Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Guaiazulenesulfonate sodium
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others
  • Indication
    folic acid antagonists

Chemical Information

  • CAS Number
    6223-35-4
  • Formula Weight
    300.35
  • Molecular Formula
    C15H17NaO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:30 mg/mL (99.88 mM)
  • SMILES
    [Na+].CC(C)c1ccc(C)c2c(cc(C)c2c1)S([O-])(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cao T Li Y Yang Z et al. Synthesis and Biological Evaluation of 3 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent[J]. Chemical Biology & Drug Design 2016 88(2):264-271.
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